Wingless
WNT1 is a gene that encodes the WNT1 protein. It is a proto-oncogene involved in regulating embryonic development and is highly conserved among animals. WNT1 was previously known as INT1 in mammals and Wg (or "wingless") in Drosophila. In 1987, it was discovered that they were the same gene (i.e. they were homologous), and the gene was subsequently renamed WNT1 as a portmanteau of wingless and int-1.
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum.
Ascension
- 2024-06-21T00:00:00.000000Z
Nonconform
- 2021-10-01T00:00:00.000000Z
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